Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia: Study of Efficacy of the Treatment and the Number of Sessions Required
Platelet-rich plasma (PRP) treatment is a fast becoming very popular modality of hair loss treatment with very minimal side effects. PRP is an autologous (your own) high concentration of platelets in a 5ml of plasma. Platelets release a very high concentration of bio active growth factors that are used in the treatment of hair loss as well as other dermatological and musculoskeletal conditions. Androgenetic alopecia (pattern hair loss) is a hereditary, androgen-dependent condition which is extremely common and notoriously difficult to treat. The treatment modalities are limited to topical minoxidil and oral/topical finasteride. Treatments like laser therapy have been shown to provide limited success and are extremely inconvenient. As for minoxidil and finasteride concerns about long-term efficacy and safety have been established. The recent study here show the efficacy of PRP along with microneedling in the treatment of hair loss, along with assessing the number of sessions required.
Androgenetic alopecia (pattern hair loss) is genetic, hormonal-influenced, non-scarring patterned hair loss which affects both male and female. Only two FDA-approved medications are available for AGA, i.e. minoxidil and finasteride. However, few drawbacks of minoxidil, such as daily twice application, dryness or irritation, initial shedding of the telogen hairs, and associated side effects of finasteride, including reduced libido.
PRP is one such modality which is a simple and safe procedure which has the ability to improve hair growth at affordable costs. Hair growth cycle is regulated by different many different growth factors that are involved in the hair follicle formation. PRP releases growth factors from the platelet concentrate and also stimulates molecular signaling pathways, which promotes hair growth and prevent cellular death. The procedure is safe with minimal side effects. Pain during the therapy is a limitation. 95% of patients could tolerate associated mild discomfort during the procedure and in the remaining it can was alleviated with topical EMLA. When activated with calcium chloride, the growth factors are released from platelets within 10 min. Again, here is another study that has demonstrated PRP as an effective treatment for hair loss…
Number of PPP sessions required It is initially recommended to do a course of four treatments, one per month to ascertain best results. it is recommended to come in for a review and a top up three months afterwards. Following this method studies have showed a significant increased rate in hair density at 3 months and 6 months, respectively, with reductions in hair loss, improved thickness and hair growth. Three months after treatment, patients can present clinical improvement in the hair counts, hair thickness, hair root strength, and overall alopecia, whereas there has been no improvement in comparison to control group studies.
Overall from this recent study, it shows again that PRP, also along with microneedling is effective for the treatment of hair loss. This study identifies that PRP augments the effects of conventional hair loss treatments like minoxidil and finasteride. This reports that a minimum of four sessions is required to achieve the desired effect. However, it should be taken into account the consideration of individual patient factors, some may require more than 4 sessions. Guidelines and protocols on the various steps involved in the preparation of PRP like the correct PRP kit, centrifugation, platelet concentration levels, and evaluation methods are important in obtaining consistent results.
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