Orthobiologic considerations in tissue degradation, repair and regeneration. Part 1
Orthobiologic considerations in tissue degradation, repair and regeneration. In relation to chronic progressive musculoskeletal disease.
Progressive musculoskeletal disease
Musculoskeletal conditions comprise of more than 150 diagnoses that affect the locomotor system; that is, muscles, bones, joints and associated tissues such as tendons, ligaments, and occasionally nearby nerves – neuromusculoskeletal. Musculoskeletal conditions can range hugely from injury, being those that arise suddenly and are short-lived, such as fractures, sprains and strains, to lifelong conditions associated with ongoing pain and disability.
Musculoskeletal conditions are typically characterised by pain (intermittent or persistent) and limitations in mobility and function. The most common and disabling musculoskeletal conditions are progressive diseases like degenerative osteoarthritis, back and neck pain, fractures associated with bone fragility, injuries and systemic inflammatory conditions such as rheumatoid arthritis.
Musculoskeletal conditions often include:
joints, such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis
bones, such as osteoporosis, osteopenia and associated fragility fractures, traumatic fractures
spine, such as back and neck pain
multiple body areas or systems, such as regional and widespread pain disorders and inflammatory diseases such as connective tissue diseases and vasculitis that have musculoskeletal manifestations, for example systemic lupus erythematous.
Musculoskeletal conditions are prevalent across the life-course and most commonly affect people from adolescence through to older age. The prevalence and impact of musculoskeletal conditions is predicted to rise as the global population ages and the prevalence of risk factors for noncommunicable diseases increases, particularly in low- and middle-income settings. Musculoskeletal conditions occur commonly with other noncommunicable diseases in multimorbidity health states.
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