Autologous micrografting technology (AMT®) involves the use of autologous micrografts to stimulate/enhance the repair of damaged tissue. This study assessed the efficacy and safety of the AMT® procedures in patients with early stages of knee osteoarthritis.
The procedure involved extraction of auricular cartilage, disaggregation in 4.0 mL of saline solution, and injection of the disaggregated micrografts into the affected knee. In included patients, there was a steady improvement in knee instability, pain, swelling, mechanical locking, stair climbing, and squatting at 1- and 6-months post-procedure. Improvement in mobility was observed as early as 3 weeks post-procedure in some patients. Significant improvements were seen in mean scores of all five subscales of Knee Injury and Osteoarthritis Outcome Score between pre-procedure and 1- and 6-months post-procedure.
Autologous auricular cartilage micrografts is showing to be an effective and safe protocol in the treatment of early stage knee osteoarthritis. These encouraging findings need to be validated in a larger patient population and in a randomised clinical trial (RCT).
Study can be found here
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