Dynamic Regenerative Medicine are offering treatment of combined Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) for the treatment of joint pain i.e. arthritis and varied tendon injuries like tennis elbow and knee tendonitis etc...
Osteoarthritis is the most common joint disease. Current treatments for OA are mainly inadequate due to poor restoration of fully functional cartilage. Hyaluronic Acid joint injections are widely accepted for the treatment of pain associated with osteoarthritis. The aim of hyaluronic acid treatment is to reduce pain and improve joint fluid. Platelet Rich Plasma (PRP) has also been used to treat osteoarthrits to induce and promote cartilage regeneration. The combination of hyaluronic acid and PRP treatment have been shown to provide many advantages for tissue repair and healing. Indeed, it conjugates hyaluronic acid with PRP regenerative properties.
The recent 2016 study below evaluated the rheological and biological properties of different HA compositions in combination with PRP treatment in order to 1) identify the joint fluid increases with the HA - PRP blends combined, 2) their biological effect on osteoarthritic cartilage damage and 3) HA formulations suitable for use in combination with PRP. It found that PRP addition to HA leads to a promising approach for future osteoarthritis therapy. Link: https://www.ncbi.nlm.nih.gov/m/pubmed/27310019/
When looking at the comparison of HA and PRP a 2016 study looked at HA Versus PRP with an in depth double-blind randomised controlled trial comparing clinical outcomes and effects on joint biology for the treatment of osteoarthritis, it found that no difference between HA and PRP at any time point. Also, significant improvements were seen in patient-reported outcome measures, with results favouring PRP over HA. Portraying a significant difference in patients favouring PRP. A decrease in inflammatory cells, where observed, which suggest that the anti-inflammatory properties of PRP can contribute to an improvement of symptoms. Link: http://journals.sagepub.com/doi/pdf/10.1177/0363546516665809.
Another 2016 study looked at how HA induces the further release of growth factors from PRP therapy. Identifying that PRP and HA injections are both good therapeutic options for osteoarthritis and chronic tendon inflammation. This study looked at the influence of HA on platelets in PRP by measuring releasing growth factors and concluded that the levels of growth factors released by PRP on Day 5 were increased by the addition of HA. A mixture of PRP and HA looks to be a more effective therapy than PRP or HA alone for osteoarthritis and tendon injury. Link: https://www.sciencedirect.co
Furthermore, a 2016 study by the Journal of Stem Cells and Regenerative Medicine found, when looking at a comparison trial that - combination of HA and PRP resulted to better outcomes than HA alone up to 1 year and PRP alone up to 3 months. Furthermore, the results suggest that combination of PRP and HA could potentially provide better functional outcomes in the first 30 days after treatment with both PRP and HA alone. Link: https://www.orthohealing.com/about/research/pdf/PRP+HA_knee_OA_.pdf.
Future osteoarthritis and tendonitis therapy may involve PRP combined wit HA for better clinical outcomes. Further reports reveal that clinical data demonstrate that PRP addition is not detrimental to the effect of HA and combinations of the 2 forms of treatment show very promising approaches for ongoing treatment in the future.
Find out more on how Dynamic Regenerative Medicine can help you with minimally invasive treatments for joint and tendon pains.