A comparative study of the efficacy of joint injection of different drugs in the treatment of knee pain and arthritis. March 2023.
Knee pain and osteoarthritis is extremely common and can greatly compromise quality of life. In arthritis patients, evidence suggests that intra-articular joint injection can improve joint pain and function. Several joint injection treatments are used in daily clinical practice to improve pain and disease progression, but what is the best option?
This comparison analysis compares the efficacy of different joint injections for knee pain and osteoarthritis. Seven databases were used. They used the Cochrane risk of bias tool to assess the quality and risks of biases of studies.
They included 16 randomised controlled trials with a total of 1652 patients. They study included oZone therapy, platelet rich plasma (PRP) treatment, corticosteroid, hyaluronic acid, autologous condition plasma and cell based treatment. Platelet-rich plasma (PRP) joint injection treatment had the highest likelihood of being the best treatment in reducing pain, stiffness and function scores. Furthermore, PRP outperforms other drugs in terms of reducing pain, improving function and stiffness score.
In conclusion, knee pain and mild to moderate osteoarthritis responding better with PRP injection therapy. PRP outperformed joint injection ozone, HA, CS, platelet-rich plasma-derived growth factor, and hyaluronic acid and platelet-rich plasma in terms of pain, stiffness, and dysfunction.
Study can be found here
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