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What is the most effective Injection Treatment for Knee Pain and Arthritis? March Study 2023 Update

Updated: Mar 28

A comparative study of the efficacy of joint injection of different drugs in the treatment of knee pain and arthritis. March 2023.

What is the most effective Injection Treatment for Knee Pain and Arthritis? March 2023 Update

Knee pain and osteoarthritis is extremely common and can greatly compromise quality of life. In arthritis patients, evidence suggests that intra-articular joint injection can improve joint pain and function. Several joint injection treatments are used in daily clinical practice to improve pain and disease progression, but what is the best option?

This comparison analysis compares the efficacy of different joint injections for knee pain and osteoarthritis. Seven databases were used. They used the Cochrane risk of bias tool to assess the quality and risks of biases of studies.

They included 16 randomised controlled trials with a total of 1652 patients. They study included oZone therapy, platelet rich plasma (PRP) treatment, corticosteroid, hyaluronic acid, autologous condition plasma and cell based treatment. Platelet-rich plasma (PRP) joint injection treatment had the highest likelihood of being the best treatment in reducing pain, stiffness and function scores. Furthermore, PRP outperforms other drugs in terms of reducing pain, improving function and stiffness score.

In conclusion, knee pain and mild to moderate osteoarthritis responded better to PRP injection therapy. PRP outperformed joint injection ozone, HA, cortisone, platelet-rich plasma-derived growth factor, and hyaluronic acid and platelet-rich plasma in terms of pain, stiffness, and dysfunction.

Study can be found here


Don’t let joint pain, joint damage, sports injuries or arthritis get in the way of allowing you to do what you want. Schedule a consultation at Dynamic Regenerative Medicine today, and let us treat your condition, provide pain relief and get you back to your full and active lifestyle. We have clinics operating out of Solihull (Henley-In-Arden) and Birmingham (Edgbaston).

Call us today on 01564330773



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