There comparison effects of joint injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial.
BACKGROUND
This study looked to compare the short and long-term efficacy of the intra articular joint injections of hyaluronic acid (HA), platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), and ozone in patients with knee osteoarthritis (OA).
METHODS
In this randomised clinical trial, 238 patients with mild to moderate knee OA were randomized into 4 groups: HA (3 doses weekly), PRP (2 doses with 3 weeks interval), PRGF (2 doses with 3 weeks interval), and Ozone (3 doses weekly). Our outcome measures were the mean changes from baseline (immediately from the first injections) until 2,6, and 12 months post intervention, then the results were analyse.?
RESULTS
A total of 200 patients enrolled in the final analysis. The mean age of patients was 56.9 ± 6.3 years, and 69.5% were women. In 2 months follow up, significant improvement of pain, stiffness, and function were seen in all groups compared to the baseline. In 6 month follow up HA, PRP, and PRGF groups demonstrated better therapeutic effects in all scores in comparison with ozone. At the end of the 12th month, only PRGF and PRP groups had better results versus HA and ozone groups in all scores. Despite the fact that ozone showed some good early results, its effects begin to wear off earlier than other products.
CONCLUSIONS
Ozone injection had good starting effects, but its therapeutic effects did not persist after 6 months. At the 6-month follow up, PRP, PRGF and HA were superior to ozone. Only patients in PRP and PRGF groups improved symptoms persisted for 12 months. Therefore, these products could be the preferable choices for long-term management.
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