Allogenic platelet-rich plasma (PRP) therapy for treating cartilage injury: A systematic review of the evidence on the basic sciences for potential future applications. Nov 2023.
It is apparent that whilst many studies are available regarding Platelet-Rich-Plasma (PRP), the larger majority of these have been mainly focused on autologous sources, and for good reason. Issues relating to allogenic PRP have been consciously avoided owing to concerns of cross infectivity, reaction and immune rejection. However, this gas been revisited and is of interest since progress has demonstrated its safety and its efficacy. The present systematic review was therefore conducted to investigate advances made in this area, with the aim to provide a wider and deeper understanding of studies relevant to the application of allogenic PRP in cartilage repair.
It was identified that, allogenic PRP promotes cell proliferation, cartilage matrix production and anti-inflammatory effects. The in animals studies, there was histological evidence of significant acceleration of cartilage repair. Despite several conflicting reporrs, all studies agreed that allogenic PRP is safe and efficacious for cartilage repair, with the advantages of allogenic sources apparent.
Full study can be to be here.
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