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Comparison between joint injection of placebo, steroids, hyaluronic and PRP for knee pain OA

Comparison between intra-articular infiltrations of placebo, steroids, hyaluronic and PRP for knee osteoarthritis: a Bayesian network meta-analysis

Treatment for knee pain and osteoarthritis Birmingham


Knee pain related to osteoarthritis is the biggest form of joint arthritis causing huge disability and poor quality of life. Current joint injection treatment involves corticosteroid, platelet rich plasma (PRP) and hyaluronic acid. Regarding the efficacy of these intra-articular injections, current evidence is controversial. The superiority of one technique over another is questioned and debates are ongoing. The purpose of the present review and comparison study was to compare and investigate the efficacy of these joint injection treatments in patients with knee pain related to osteoarthritis (OA). A Bayesian network meta-analysis of randomised clinical trials (RCTs) was conducted comparing patient outcomes at 3, 6 and 12-months of follow-up.

Materials and methods

All the clinical trials comparing the outcomes of two or more joint injection treatment of interest for knee OA were considered for inclusion.


Data from 30 clinical trials involving a total of 3463 patients were collected. At 3-months follow-up, PRP showed the best outcome, followed by the corticosteroid and hyaluronic acid injection treatment. At 6-months follow-up, PRP showed the best outcome, followed by hyaluronic acid, corticosteroid and placebo. At 12-months follow-up, PRP showed the best clinical outcomes, followed by the hyaluronic acid, placebo and corticosteroid.


Intra-articular joint injections of PRP demonstrated the best overall outcome compared to steroids, hyaluronic acid and placebo for patients with knee pain related to osteoarthrosis at 3, 6 and 12-months follow-up. Quite clearly demonstrating reduced pain and improved function. Furthermore, this is a natural, safe, easy treatment that holds practically no side-effects. In addition, PRP treatment in combination with hyaluronic acid is recommended for joint preservation and further improving function.


Don’t let pain, joint damage, sports injuries or arthritis get in the way of allowing you to do what you want. Schedule a consultation at Dynamic Osteopaths & Regenerative Medicine today, and let us treat your injury, provide pain relief and get you back to your full and active lifestyle. We have clinics operating out of Solihull (Henley-In-Arden), Birmingham (Harborne/Edgbaston) & Bromsgrove (Barnt Green).

Call us today 01564 330773


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