Patient Satisfaction and Clinical Effects of Platelet-Rich Plasma (PRP Treatment) on Male and Female Hair Loss Patients.
The biggest cause of hair loss is androgenetic alopecia, which is know as pattern hair loss. In women, androgenetic alopecia may be. Common approaches for treating pattern hair loss include oral 5α-reductase inhibitors (i.e., finasteride or dutasteride) from spreading the conversion of testosterone into dihydrotestosterone, along with the topical application of minoxidil, which in some cases. Am be used to shorten the resting phase (telogen phase) of the hair cycle, with the result that the growth phase (anagen phase) is reached faster. As the this a daily treatment process, both treatments are often associated with poor patient compliance, and side effects (e.g., impotence, depression) can occur with finasteride in particular.
Laser therapy (LLLT) was also proposed as an alternative treatment option, used to try and stimulate of hair follicles, however, efficacy and evidence is poor in the beneficial use of laser treatment for hair loss. Over the past decade, platelet-rich plasma (PRP) has become a very common treatment for hair loss. The PRP's growth factors and cytokines are used to initiate a high potency tissue stimulus. Research demonstrated that these growth factors can reduce tissue degeneration and prolong the anagen phase of the hair cycle, via a natural biological process. From a clinical point of view, evidence demonstrating positive effects from PRP treatments is continuing to grow fast. This recent October 2022 study, investigated the satisfaction with PRP treatments as the primary endpoint.
PRP is a safe intervention to treat male and female pattern hair loss (androgenetic alopecia) and is associated with clinical improvements and success, including good patient satisfaction. Evans et al recently reviewed 30 studies, including 687 patients on PRP for the treatment for hair loss. All of these clinical studies reported beneficial results, which the vast majority reaching statistical significance on a measured outcome. The meta-analyses showed that PRP treatment increases hair thickness and density. It was concluded that PRP is an autologous treatment that lacks serious adverse effects and effectively improves hair density and hair thickness in men and women with androgenetic alopecia.
With regards to the treatment of female pattern hair loss with PRP, it has be in shown in numerous cases that PRP has provided excellent efficiency through hair density evaluation. This was shown the systematic review and meta-analyses, a total of 42 studies of 1,569 cases, including 776 female, covering 16 randomised trials and 26 observational trials. In comparison to the control groups, PRP has demonstrated effective successful outcomes with hair density in treating female pattern hair loss.
Providing a high patient satisfaction and positive clinical outcomes, this new study is in line with current literature. In contrast to the existing studies, this new study assessed the clinician's satisfaction also, and clinician's satisfaction rates are very similar. Concerning the clinical signs, improved hair density was the most frequent sign from the patients and new hair growth.
As reported already in literature, datas suggests that treatment efficacy is similar for male and female pattern hair loss. In this study, they investigated a serial single-therapy with PRP. Recently, protocols combining PRP with other hair loss treatment options were published. PRP combined with minoxidil 5% revealed effective results for hair density, hair count, anagen and telogen percentages, and anagen/telogen ratio. Microneedling, PRP and topical minoxidil 5% has been also be shown to be much more effective than topical minoxidil 5% alone. Furthermore, researcher Gowda reported statistically superior results of PRP plus minoxidil vs. minoxidil alone and vs. a dermaroller plus minoxidil. Another comparative study reported good response in the minoxidil 5% side in 41%, moderate response in 20%, and poor response in 39%, whereas significantly higher for the PRP plus minoxidil 5% side in terms of response rate. In addition , researcher Vaaruni reported excellent improvement for most of their patients in the Minoxidil plus PRP group vs minoxidil alone. A systematic review and analysis was published comparing various treatment options for hair loss. PRP had the highest surface ranking value in the network for androgenetic alopecia, with effectiveness and safety. Along side these ranking, dutasteride also ranking higher than finasteride.
To conclude this study revealed encouraging results for the successful treatment of pattern hair loss with PRP for both men and women. The autologous treatment was rated with high satisfaction scores without the occurrence of adverse events and can be considered a safe and effective treatment for hair loss. As patient satisfaction scores are subjective to some extent, we added clinician satisfaction scores and found out that they were consistent with the scores from the patients. This study confirms the positive patient satisfaction scores and the high safety profile of PRP injections. Therefore, it is considered that PRP is a very a valuable treatment option for male and female pattern hair loss.
Full study can be found here Patient Satisfaction and Clinical Effects of Platelet-Rich Plasma on Pattern Hair Loss in Male and Female Patients
Alongside PRP, occasionally, it is fundamentally important to suppress the conversion of DHT, which can lead towards hair loss. Here commonly finasteride or more recently dutasteride can be used but not everybody is wanting to risk the potential side effects of pill form. Fortunately, topical dutasteride mesotherapy can be a good option to suppress DHT, without systemic side-effects. This is frequently used in combination with PRP treatment.
We are very proud to say we are the UK’s leading provider of advanced PRP treatment and have been providing this fantastic treatment with ongoing success for almost 10 years, providing over 13,000 treatments to date. We are hugely proud of the significant help and success this has provided to many people, literally changing lives.
Furthermore, we offer the best quality and concentration of PRP at very affordable prices. This is for two reasons, 1) we are the UK distributor for PRP iStem, which allows us to significantly reduce prices, and 2) we truly believe that that payment has to be justifiable as you are using patient’s own cells.
Our Clinic Director and Clinical Scientist Mr Adam Whatley is continuing on clinical research in this fascinating area of platelets and stem cells, and to offer the best level of clinical practice to all patients. PRP treatment has been ongoingly praised for its huge safety profile and effectiveness for various different conditions are very different areas of clinical medicine. Risks and adverse complications associated with PRP treatment is practically non-existent.
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