• Adam Whatley

Hair Loss Treatment: The Biotechnology RIGENERA® for tissue micro-grafts in Regenerative Medicine

Updated: May 8


The Modern and Sophisticated Technology of Rigenera Activa®


The first studies that led to the development of Rigenera® technology date back to 2006 and were conducted by two Italian researchers, who have a particular interest in Biotechnology applied to stem cells. Rigenera® is a Class I medical device manufactured in Italy by HBW, worldwide patented and marketed all over the world.


The Rigenera® system has been utilised since 2013 and in recent years it is becoming increasingly successful in the European and International countries. Although Rigenera® technology was born from oral and dental surgeries, today it is applied in many areas of regenerative medicine such as in the treatment of hair restoration and wound healing in reconstructive plastic surgery. Moreover it is widely used in aesthetic medicine for the treatment of skin rejuvenation.



Hair Loss Treatment: The Biotechnology RIGENERA® for tissue micro-grafts in Regenerative Medicine


What is Rigenera®?


Rigenera® is a mechanical disgregator of biological tissues (i.e. dermis, connective tissue, bone tissue, dental pulp and cartilaginous tissue) able to autologously, homologously and minimally invasively obtain micrografts. The device is made up of a 100-hole steel grid on which six micro-scalpel are inserted and of a filter that allows the selection of cells with a diameter of about 50 microns. Studies have shown that the cell population obtained after the mechanical disgregation of different tissues is made up of cell progenitors with a vitality of over 90%. Both of these properties are at the basis of the regenerative potential of micro-grafts.

A great advantage in using Rigenera® is that the collection, processing and implantation of micro-grafts take place at the same surgical time, where donor and recipient are in fact the same person.

The Rigenera® method does not involve any risk for the patient as it is mini-invasive and it involves taking small pieces of skin, even in case of large lesions.

Methodic is simple and with low risk.


The invasiveness of medical treatment is minimal as Rigenera® technology is a single application without additional dressings (no pharmaceutical products, no chemical products) except for physiological solution. Similarly, there is no risk to the staff, as the use is simple and intuitive and it is applicable also in the outpatient clinic.



Micro-graft drives the tissue rigeneration


Rigenera® offers the advantage of obtaining calibrated 50-70 microns micro-grafts, immediately ready for use by bypassing the step of culturing and expanding in vitro. The cells' sizes are important in the regenerative medicine because numerous scientific evidence show that cell progenitors are localised in the "side population". This subgroup is characterised by 'staminality', that is the ability to replicate and differentiate in different cell types.


Cell death in grafts vs micro-grafts


A problem associated with traditional tissue grafts is the high death rate of progenitors cells due to the breakdown of blood vessels during the recovery process of the grafts themselves. Rigenera® technology overcome this issue because the fast mechanical fragmentation of the tissues, in order to obtain cells, does not influence cell viability as shown in several articles published in recent years (Finding et al., JCP 2015, Monti et al., JCP 2017).




Conclusions


Micro-grafts is a key tecnique in tissue regeneration because it is the fastest and most effective way for clinical use of stem cells. Micro-graft can be obtained easily and safely using the Rigenera® tissue breaker, which is based on an exclusively mechanical action, at a single surgical time, without the addition of any chemical or pharmaceutical element, and which does not apply significant manipulation that legally limits its use. Rigenera® is today the only class 1 medical device with CE and FDA certification that allows the preparation of microinstructions through a mechanical process for tissue regeneration treatments.


Rigenera® is protected by a worldwide patent:


It is a unique medical device in the world. It is one of the great novelties in regenerative medicine that has already demonstrated its effectiveness in dealing with wound healing in reconstructive plastic surgery and in the care of androgenetic alopecia in aesthetic medicine. Moreover it begins to demonstrate extraordinary results in parallel fields such as regeneration of cartilage in orthopaedics.






GET IN TOUCH TO FIND OUT MORE OR SCHEDULE A FREE CONSULTATION

Don’t let the signs of ageing affect your confidence or get in the way of life. Schedule a FREE consultation with Dynamic Regenerative Medicine today, and let us treat your hair loss and provide you with full confidence again. We have clinics operating out of Solihull (Henley-In-Arden) and Birmingham.

Call us today 01564 330773

www.dynamicregenmedicine.co.uk


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