PRP and Hyaluronic Acid Combination For The Treatment of Osteoarthritis
Knee osteoarthritis is the most common progressive degenerative disease of joints caused by cartilage injury, degradation of the joint cartilage and bone spurribg. Various treatments are used in the treatment of arthritis symptoms of patients with knee osteoarthritis, including analgesics (pain killers), physical rehabilitation therapy and joint injections.
Platelet‑rich plasma (PRP) is an autologous and multifunctional high concention of platelets of the blood, which is used to stimulate the cartilage healing process, slow the progression of degenerative changes and improve the damage caused by articular joint disease.
Hyaluronic acid (HA) is also an effective treatment used for patients with variuos types of osteoarthritis. In the study below, the effectiveness of PRP and HA in combination administered via joint injections for patients with knee osteoarthritis was analysed. In the below study a total of 360 patients with knee osteoarthritis were out into four different double blind treatment groups as follows: 1) with PRP, 2) with HA in combination with PRP. and 3) placebo groups. Following treatment, all patients were evaluated and the study demonstrated that PRP and HA treatment significantly improved pain, and PRP treatment was determined to be significantly more effective than HA treatment alone. PRP and HA combination treatment significantly improved joint pain that is associated with osteoarthritis , reduced humoral and cellular immune responses and promoted tissue repair and cell growth - which improved the patients' parameters compared with PRP or HA treatment alone.
The results suggest that PRP and HA combination can be an effective treatment option for patients with knee osteoarthritis in the future.
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