Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies
August 2023 review
Tendinopathy is a very common medical complaint that includes inflammatory and degenerative tendon changes caused by trauma or overuse injuries. The basis of of tendinopathy is complicated, and no perfect treatment is currently available. Platelet-rich plasma (PRP) is an autologous plasma treatment commonly used within regenerative medicine containing a variety of bioactive cytokines and protein components. Various studies over the past 15 years have found that PRP has the therapeutic potential to promote healing and regeneration via cell proliferation and differentiation, regulate angiogenesis (new blood vessel formation), increase extracellular matrix synthesis, and modulate inflammation in degenerative tendons. Therefore, PRP has been widely used as a promising therapeutic agent for tendinopathy.
This recent August 2023 review provides a deeper biological understanding of the molecular and cellular mechanisms by which PRP promotes tendon healing and to better understand how PRP affects tendinopathy.
PRP is a safe, easily accessible and effective biological treatment. PRP has been gradually applied in the treatment of many consitions within the field of musculoskeletal, and has shown many curative effects. Clinical scientists have conducted many trials over the past decade, looking into the efficacy of PRP for tendon damage. However, different protocols still exist, this can then add to differences among studies, PRP ingredient, mode of administration, donor (patient), and disease (type, stage). This article focuses on the disease process of tendinopathy and combines the PRP mechanism with the disease process of tendinopathy, thereby better understanding how PRP aids in the healing and recovery of tendinopathy and the reasons for the differences in the clinical outcomes. Moreover, based on fundamental research, this article integrates the specific molecular and cellular mechanisms by which PRP manipulates tendon healing, including promoting tendon regeneration and modulating inflammation in tendinopathy.
Please find full review here.
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