Mr Adam Whatley
Tissue Bio-engineering
Chondrogenesis and the Anti-catabolic Protection of Orthobiological Intervention
Articular cartilage defects (damage) have long-term progressive impacts on functional impairment and pain of joints, this, as a consequence of poor healing and progressive degradation. The existing methods for bone cartilage regeneration involving minimally invasive intervention are microfracture, intra-articular injection or bio-scaffold implantation. But still, hyaline cartilage with appropriate mechanical properties needs further investigation.
The following characteristics including cost-effectiveness and easy accessibility of cartilage repair techniques for the increasingly required applied clinical use. Endogenous bio-repair of cartilage has been to stimulate the repair potential of endogenous tissue with exogenous substances, such as autologous platelet concentrate and hydrated hydrogel implantation.
Hyaluronic acid has another good biocompatibility with chemical and physical relational properties. Hyaluronic acid is also very well hydrated and has the capability to slow the progression of degradative changes and simulate the extracellular matrix. Hyaluronic acid provides matrix for cell adhesion, proliferation and differentiation. Thus, promoting the stimulation of chondrogenic and osteogenic stem cells that act to aid cartilage repair as well as subchondral bone. However, although having very good benefits, it has been identified that the application of singular hyaluronic acid stimulated insufficient cartilage repair. It is the addition of bioactive protein growth factors which enable facilitation and progression of chondrogenesis (new cartilage cell growth). Autologous platelet concentrate or PRP treatment provides an essential role here in providing facilitation of chondrogenesis and bone repair. This providing far superior clinical outcomes in repair of localised defects using hyaluronic acid in combination with platelet concentrate – in interventional methods known as orthobiologics. Furthermore, hyaluronic acid and platelet concentrate have the ability to provide chondroprotection, hereby, reducing friction, catabolic changes and inflammatory cytokines like tumor necrosis factor.
Regenerative orthobiologics aims for joint preservation and articular regeneration in order to reduce pain and inflammation, to slow the progression of degenerative changes and to restore functional capacity. Regenerative methods are continuing to be increasingly adopted due to the physiological structure of articular cartilage, having limited self repair capacity. This clinical need leads
to the ongoing development of therapies to promote chondrogenesis and osteogenesis.
Here at Dynamic Regenerative Medicine in Birmingham we have been adopting these unique biological treatments, with the best technologies for several years, with increasing fantastic ongoing long term success. Mild to moderate cases of cartilage damage and osteoarthritis have been showing success rates of beyond 95%. severe cases of osteoarthritis difficult to treat at success rates of 30%. Multiple factors are considered, like age and progression of deterioration. in comparison to steroids (cortisone injections), we are finding much better success long term, with orthobiologics for the non-surgical treatment and management joint pain and cartilage damage.
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Don’t let pain, joint damage, sports injuries or arthritis get in the way of allowing you to do what you want. Schedule a consultation at Dynamic Regenerative Medicine today, and let us treat your injury, provide pain relief and get you back to your full and active lifestyle. We have clinics operating out of Solihull (Henley-In-Arden) and Birmingham (Edgbaston).
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